A selection of work, grouped by research line. This is a curated set — the complete record runs to more than 300 items and lives on the profiles below, which are always current.

Complete and up-to-date lists ORCID · Google Scholar · PubMed · FRIS research portal · KU Leuven Lirias

The FRIS portal holds the fullest record — over 300 items, identity-linked to KU Leuven.

A caution for anyone searching by name: PubMed’s Van Oudenhove L also returns work by an unrelated researcher in entomology. The FRIS and ORCID profiles do not have this problem, and every entry below was checked against its PubMed author list.

Gastrointestinal symptom, pain, and fatigue perception

Multimodal approach to identify neuropsychophysiological subgroups in myalgic encephalomyelitis/chronic fatigue syndrome and their relevance for rehabilitation: protocol for a mechanistic cross-sectional and longitudinal study

Dooms Y, Qiu L, Coppieters I, Vergaelen E, Claes S, Dupont P, Hehl M, Cuypers K, Engler H, Dombrowski K, Verbeke K, Van den Bergh O, Raes J, Van Oudenhove L, Van Den Houte M, Bogaerts K

Brain, behavior, & immunity - health 2026;56():101299.

doi:10.1016/j.bbih.2026.101299 PubMed 42472232

The psychobiological model of disorders of gut-brain interaction: introduction of a novel, integrated, and testable model

Guadagnoli L, Heathcote LC, Van Oudenhove L, Elsenbruch S, Keefer L

The lancet. Gastroenterology & hepatology 2025;10(11):1041-1052.

doi:10.1016/S2468-1253(25)00205-5 PubMed 40886718

Rome Foundation Working Team Report on overlap in disorders of gut-brain interaction

Barbara G, Aziz I, Ballou S, Chang L, Ford AC, Fukudo S, Nurko S, Olano C, Saps M, Sayuk G, Siah KTH, Van Oudenhove L, Simrén M

Nature reviews. Gastroenterology & hepatology 2025;22(4):228-251.

doi:10.1038/s41575-024-01033-9 PubMed 39870943

Psychological Processes, Not Physiological Parameters, Are Most Important Contributors to Symptom Severity in Patients With Refractory Heartburn/Regurgitation Symptoms

Guadagnoli L, Geeraerts A, Geysen H, Pauwels A, Vanuytsel T, Tack J, Van Oudenhove L

Gastroenterology 2023;165(4):848-860.

doi:10.1053/j.gastro.2023.06.019 PubMed 37394015

Gut-brain axis dysfunction underlies FODMAP-induced symptom generation in irritable bowel syndrome

Wu J, Masuy I, Biesiekierski JR, Fitzke HE, Parikh C, Schofield L, Shaikh H, Bhagwanani A, Aziz Q, Taylor SA, Tack J, Van Oudenhove L

Alimentary pharmacology & therapeutics 2022;55(6):670-682.

doi:10.1111/apt.16812 PubMed 35166384

Role of brain imaging in disorders of brain-gut interaction: a Rome Working Team Report

Mayer EA, Labus J, Aziz Q, Tracey I, Kilpatrick L, Elsenbruch S, Schweinhardt P, Van Oudenhove L, Borsook D

Gut 2019;68(9):1701-1715.

doi:10.1136/gutjnl-2019-318308 PubMed 31175206

Visceral hypersensitivity is associated with GI symptom severity in functional GI disorders: consistent findings from five different patient cohorts

Simrén M, Törnblom H, Palsson OS, van Tilburg MAL, Van Oudenhove L, Tack J, Whitehead WE

Gut 2018;67(2):255-262.

doi:10.1136/gutjnl-2016-312361 PubMed 28104632

Neuromodulators for Functional Gastrointestinal Disorders (Disorders of Gut-Brain Interaction): A Rome Foundation Working Team Report

Drossman DA, Tack J, Ford AC, Szigethy E, Törnblom H, Van Oudenhove L

Gastroenterology 2018;154(4):1140-1171.e1.

doi:10.1053/j.gastro.2017.11.279 PubMed 29274869

Biopsychosocial Aspects of Functional Gastrointestinal Disorders

Van Oudenhove L, Crowell MD, Drossman DA, Halpert AD, Keefer L, Lackner JM, Murphy TB, Naliboff BD, Levy RL

Gastroenterology 2016;():.

doi:10.1053/j.gastro.2016.02.027 PubMed 27144624

Learned Fear of Gastrointestinal Sensations in Healthy Adults

Ceunen E, Zaman J, Weltens N, Sarafanova E, Arijs V, Vlaeyen JW, Van Oudenhove L, Van Diest I

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2016;14(11):1552-1558.e2.

doi:10.1016/j.cgh.2016.04.035 PubMed 27155550

Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism

Vanuytsel T, van Wanrooy S, Vanheel H, Vanormelingen C, Verschueren S, Houben E, Salim Rasoel S, Tόth J, Holvoet L, Farré R, Van Oudenhove L, Boeckxstaens G, Verbeke K, Tack J

Gut 2014;63(8):1293-9.

doi:10.1136/gutjnl-2013-305690 PubMed 24153250

Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia

Vanheel H, Vicario M, Vanuytsel T, Van Oudenhove L, Martinez C, Keita ÅV, Pardon N, Santos J, Söderholm JD, Tack J, Farré R

Gut 2014;63(2):262-71.

doi:10.1136/gutjnl-2012-303857 PubMed 23474421

A multidimensional model of psychobiological interactions in functional dyspepsia: a structural equation modelling approach

Jones MP, Coppens E, Vos R, Holvoet L, Luyten P, Tack J, Van Oudenhove L

Gut 2013;62(11):1573-80.

doi:10.1136/gutjnl-2012-302634 PubMed 22917658

The role of psychosocial factors and psychiatric disorders in functional dyspepsia

Van Oudenhove L, Aziz Q

Nature reviews. Gastroenterology & hepatology 2013;10(3):158-67.

doi:10.1038/nrgastro.2013.10 PubMed 23358396

Determinants of symptoms in functional dyspepsia: gastric sensorimotor function, psychosocial factors or somatisation?

Van Oudenhove L, Vandenberghe J, Geeraerts B, Vos R, Persoons P, Fischler B, Demyttenaere K, Tack J

Gut 2008;57(12):1666-73.

doi:10.1136/gut.2008.158162 PubMed 18625692

A controlled crossover study of the selective serotonin reuptake inhibitor citalopram in irritable bowel syndrome

Tack J, Broekaert D, Fischler B, Van Oudenhove L, Gevers AM, Janssens J

Gut 2006;55(8):1095-103.

doi:10.1136/gut.2005.077503 PubMed 16401691

Appetite, food intake & reward

Caloric labels do not influence taste pleasantness and neural responses to erythritol and sucrose

Budzinska A, Byl L, Teysseire F, Flad E, Dupont P, Wölnerhanssen B, Meyer-Gerspach AC, Van Oudenhove L, Weltens N

NeuroImage 2025;308():121061.

doi:10.1016/j.neuroimage.2025.121061 PubMed 39884412

Neural responses to oral administration of erythritol vs. sucrose and sucralose explain differences in subjective liking ratings

Budzinska A, Teysseire F, Flad E, Dupont P, Wölnerhanssen B, Meyer-Gerspach AC, Van Oudenhove L, Weltens N

Appetite 2024;200():107422.

doi:10.1016/j.appet.2024.107422 PubMed 38788930

The circulating and central endocannabinoid system in obesity and weight loss

Mattelaer N, Van der Schueren B, Van Oudenhove L, Weltens N, Vangoitsenhoven R

International journal of obesity (2005) 2024;48(10):1363-1382.

doi:10.1038/s41366-024-01553-z PubMed 38834796

Erythritol and xylitol differentially impact brain networks involved in appetite regulation in healthy volunteers

Meyer-Gerspach AC, Wingrove JO, Beglinger C, Rehfeld JF, Le Roux CW, Peterli R, Dupont P, O'Daly O, Van Oudenhove L, Wölnerhanssen BK

Nutritional neuroscience 2022;25(11):2344-2358.

doi:10.1080/1028415X.2021.1965787 PubMed 34404339

Motilin-induced gastric contractions signal hunger in man

Tack J, Deloose E, Ang D, Scarpellini E, Vanuytsel T, Van Oudenhove L, Depoortere I

Gut 2016;65(2):214-24.

doi:10.1136/gutjnl-2014-308472 PubMed 25539673

Does the gut-brain axis control anticipatory food reward? Novel insights from bariatric surgery

Van Oudenhove L

Gut 2014;63(6):868-9.

doi:10.1136/gutjnl-2013-305488 PubMed 23990629

Where is the comfort in comfort foods? Mechanisms linking fat signaling, reward, and emotion

Weltens N, Zhao D, Van Oudenhove L

Neurogastroenterology and motility 2014;26(3):303-15.

doi:10.1111/nmo.12309 PubMed 24548257

Fatty acid-induced gut-brain signaling attenuates neural and behavioral effects of sad emotion in humans

Van Oudenhove L, McKie S, Lassman D, Uddin B, Paine P, Coen S, Gregory L, Tack J, Aziz Q

The Journal of clinical investigation 2011;121(8):3094-9.

doi:10.1172/JCI46380 PubMed 21785220

Microbiota-gut-brain signalling, stress & affect

The HDAC inhibitor sodium butyrate moderately enhances long-term fear extinction memory retrieval in humans

Ribbens C, Peeters L, Van Oudenhove L, Vervliet B, Dalile B

Molecular psychiatry 2026;():.

doi:10.1038/s41380-026-03802-1 PubMed 42557391

Variability in threat processing is related to endogenous butyrate levels in healthy men

Dalile B, Van Oudenhove L, Verbeke K, Vervliet B

Biological psychology 2025;200():109097.

doi:10.1016/j.biopsycho.2025.109097 PubMed 40759334

Circulating short chain fatty acids are associated with depression severity and predict remission from major depressive disorder

Schiweck C, Dalile B, Balliet A, Aichholzer M, Reinken H, Erhardt F, Freiling J, Bouzouina A, Uckermark C, Reif A, Verbeke K, van Oudenhove L, Edwin Thanarajah S

Brain, behavior, & immunity - health 2025;48():101070.

doi:10.1016/j.bbih.2025.101070 PubMed 40761299

Probiotic-mediated modulation of gut microbiome in students exposed to academic stress: a randomized controlled trial

Vázquez-Castellanos JF, Maciel LF, Wauters L, Gregory A, Van Oudenhove L, Geboers K, Verbeke K, Smokvina T, Tack J, Vanuytsel T, Derrien M, Raes J

NPJ biofilms and microbiomes 2025;11(1):140.

doi:10.1038/s41522-025-00776-w PubMed 40691449

Colonic butyrate administration modulates fear memory but not the acute stress response in men: A randomized, triple-blind, placebo-controlled trial

Dalile B, Fuchs A, La Torre D, Vervliet B, Van Oudenhove L, Verbeke K

Progress in neuro-psychopharmacology & biological psychiatry 2024;131():110939.

doi:10.1016/j.pnpbp.2024.110939 PubMed 38199487

Lactobacillus rhamnosus CNCM I-3690 decreases subjective academic stress in healthy adults: a randomized placebo-controlled trial

Wauters L, Van Oudenhove L, Accarie A, Geboers K, Geysen H, Toth J, Luypaerts A, Verbeke K, Smokvina T, Raes J, Tack J, Vanuytsel T

Gut microbes 2022;14(1):2031695.

doi:10.1080/19490976.2022.2031695 PubMed 35130109

Colon-delivered short-chain fatty acids attenuate the cortisol response to psychosocial stress in healthy men: a randomized, placebo-controlled trial

Dalile B, Vervliet B, Bergonzelli G, Verbeke K, Van Oudenhove L

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2020;45(13):2257-2266.

doi:10.1038/s41386-020-0732-x PubMed 32521538

The role of short-chain fatty acids in microbiota-gut-brain communication

Dalile B, Van Oudenhove L, Vervliet B, Verbeke K

Nature reviews. Gastroenterology & hepatology 2019;16(8):461-478.

doi:10.1038/s41575-019-0157-3 PubMed 31123355

The neuroactive potential of the human gut microbiota in quality of life and depression

Valles-Colomer M, Falony G, Darzi Y, Tigchelaar EF, Wang J, Tito RY, Schiweck C, Kurilshikov A, Joossens M, Wijmenga C, Claes S, Van Oudenhove L, Zhernakova A, Vieira-Silva S, Raes J

Nature microbiology 2019;4(4):623-632.

doi:10.1038/s41564-018-0337-x PubMed 30718848

Neuroimaging methods & brain representations

Convergent and selective representations of pain, appetitive processes, aversive processes, and cognitive control in the insula

Kwon M, Bo K, Botvinik-Nezer R, Kragel PA, Van Oudenhove L, Wager TD

Nature communications 2026;17(1):.

doi:10.1038/s41467-026-71568-9 PubMed 41980935

Omissions of threat trigger subjective relief and prediction error-like signaling in the human reward and salience systems

Willems AL, Van Oudenhove L, Vervliet B

eLife 2025;12():.

doi:10.7554/eLife.91400 PubMed 40008871

The neurobiological basis of affect is consistent with psychological construction theory and shares a common neural basis across emotional categories

Gündem D, Potočnik J, De Winter FL, El Kaddouri A, Stam D, Peeters R, Emsell L, Sunaert S, Van Oudenhove L, Vandenbulcke M, Feldman Barrett L, Van den Stock J

Communications biology 2022;5(1):1354.

doi:10.1038/s42003-022-04324-6 PubMed 36494449

Cross-paradigm integration shows a common neural basis for aversive and appetitive conditioning

Klein S, Kruse O, Tapia León I, Van Oudenhove L, van 't Hof SR, Klucken T, Wager TD, Stark R

NeuroImage 2022;263():119594.

doi:10.1016/j.neuroimage.2022.119594 PubMed 36041642

The Brain Activation-Based Sexual Image Classifier (BASIC): A Sensitive and Specific fMRI Activity Pattern for Sexual Image Processing

van 't Hof SR, Van Oudenhove L, Janssen E, Klein S, Reddan MC, Kragel PA, Stark R, Wager TD

Cerebral cortex (New York, N.Y. : 1991) 2022;32(14):3014-3030.

doi:10.1093/cercor/bhab397 PubMed 34905775

Common and distinct neural representations of aversive somatic and visceral stimulation in healthy individuals

Van Oudenhove L, Kragel PA, Dupont P, Ly HG, Pazmany E, Enzlin P, Rubio A, Delon-Martin C, Bonaz B, Aziz Q, Tack J, Fukudo S, Kano M, Wager TD

Nature communications 2020;11(1):5939.

doi:10.1038/s41467-020-19688-8 PubMed 33230131

Generalizable representations of pain, cognitive control, and negative emotion in medial frontal cortex

Kragel PA, Kano M, Van Oudenhove L, Ly HG, Dupont P, Rubio A, Delon-Martin C, Bonaz BL, Manuck SB, Gianaros PJ, Ceko M, Reynolds Losin EA, Woo CW, Nichols TE, Wager TD

Nature neuroscience 2018;21(2):283-289.

doi:10.1038/s41593-017-0051-7 PubMed 29292378

Code and data behind the papers

Several studies have their analysis code — and in some cases data — released as their own repository in the labgas GitHub organisation. The Tools page indexes all of them, including proj-emosymp, proj-fodmap-fmri, proj_erythritol_*, proj_reflux_database_* and proj_Rome_IV_network_analysis.

Version control uses DataLad on top of git and git-annex, with code pushed to GitHub and data to GIN.